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Screening of Triazine Derivatives, Inhibitors
of MAP-Kinase p-38 Alpha, Through Mathematical Modeling
and Molecular Modeling
-- Biswajit Das, Shyamal Sharma, Pranab Ghosh,
Subhasis Mukherjee and Asim Kumar Bothra
Hexamethyl Melamine (HMM), a derivative of triazine, possesses various pharmacological actions
against breast, lungs and ovarian cancers. These derivatives bind with MAP-kinase p-38. A Quantitative
Structure-Activity Relationship (QSAR) model was developed using 16 compounds and its ability was verified by a set
of nine compounds. Several graph theoretical indices were computed along with quantum chemical
parameters and regression equations constructed. A series of triazine derivatives has also been designed and their
activity predicted. Some compounds which have high predicted activity are also suggested.
© 2009 IUP. All Rights Reserved.
Antimicrobial Study of the Unsymmetrical Tetradentate Schiff
Base and Its Cu(II), Ni(II) and VO(II) Complexes
-- C Anitha, S Prasad, M Senthil Vadivu and R Rajavel
A new series of unsymmetrical tetradentate Schiff base ligand and its Cu(II), Ni(II) and VO(II) complexes
were formed by the condensation of 5-chlorosalicylaldehyde, 2-hydroxy-1-napthaldehyde and 1,
3-diaminopropane-2-ol. The antimicrobial activity of the complexes were tested against four negative
bacteriaKlebsiella pneumoniae, Salmonella typhi, Pseudomonas aeruginosa and Escherichia coli, using nutrient agar as medium.
The zones of inhibition of the synthesized compounds were compared with the free ligand and the
standard streptomycin. All the complexes had higher activity than the free ligand and the standard. The
structural assessment of the compounds was carried out based on the elemental analysis and infrared and molar
conductivity values.
© 2009 IUP. All Rights Reserved.
C-5 Thiopropyne-Substituted Thymidine
Containing Oligonucleotides: Modulation of Oligonucleotide Duplex,
DNA/DNA and DNA/RNA Stability via Disulfide Bond
-- Ajay Kumar
Modulation of stability of oligonucleotide duplexes (DNA/DNA and DNA/RNA) containing disulfide
bonds between the two adjacent thiol groups at C-5 position of thymidine in place of phosphodiester bond at a
specific position has been reported.
© 2009 IUP. All Rights Reserved.
Solvent Polarity as a Function of Retardation Factor
in Thin-Layer Chromatography of Selected Nitro Functions:
Two Mixed Solvents
-- Anees Ahmad, Mohd. Rafatullah and Qasimullah
Solvent polarities have been related to retardation factor
(Rf) of various nitro compounds as linear functions
in binary mixtures of solvents. The average polarities of the two solvents in equal volumes have been taken as
the first estimate. Such relations may prove useful in computing polarities of mixed systems to a first
approximation and to evaluate single unknown polarities, if this value for the other solvent has been determined previously.
© 2009 IUP. All Rights Reserved.
Application of Calixarene Ionophores in PVC-Based Ion
Selective Electrodes for Heavy Metal Detection
-- Sonika Tyagi, Himanshu Agarwal and Saiqa Ikram
Functionalized calixarene molecules 26, 28-dihydroxy-25, 27-dimethoxycalix[4]arene-11, 23-diphosphonic
acid for Pb(II) and 25, 26, 27, 28-tetra-(2-dimethydithiocarbamoly-ethoxy)calix[4]arene for Hg(II) were tested
as possible ionophores in Ion Selective Electrodes (ISEs) and successfully applied for the detection of heavy
metal ions from environmental and industrial wastewaters. These membrane electrodes based on calixarene
sensors are active in the pH range of 5.5-8.5. Calixarene sensors worked satisfactorily in aqueous as well as
non-aqueous media up to 25% (v/v) non-aqueous content, and the life time of the sensors was observed to be five
months. Potentiometric selectivity coefficients as determined by Match Potential Method (MPM) indicate
excellent selectivity for Pb2+ and
Hg2+ ions. The sensors could be used successfully in the estimation of lead and
mercury in electrochemical battery wastes and also as indicator electrodes in potentiometric titration.
© 2009 IUP. All Rights Reserved.
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